Review



fty720 (s)-p  (Cayman Chemical)


Bioz Verified Symbol Cayman Chemical is a verified supplier  
  • Logo
  • About
  • News
  • Press Release
  • Team
  • Advisors
  • Partners
  • Contact
  • Bioz Stars
  • Bioz vStars
    • 90
      Buy from Supplier

    Structured Review

    Cayman Chemical fty720 (s)-p
    Effects of cytotoxicity observed with <t>FTY720</t> (S)-P exposure on HepG2 cells after 24–48 and 72 h treatment. The cells were treated with 0.3125–10 μM concentrations.
    Fty720 (S) P, supplied by Cayman Chemical, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/fty720-p/pmc12050031-46-0-5?v=Cayman+Chemical
    Average 90 stars, based on 1 article reviews
    fty720 (s)-p - by Bioz Stars, 2026-07
    90/100 stars

    Images

    1) Product Images from "In vitro investigation of the toxicological mechanisms of Fingolimod (S)-phosphate in HEPG2 cells"

    Article Title: In vitro investigation of the toxicological mechanisms of Fingolimod (S)-phosphate in HEPG2 cells

    Journal: Toxicology Research

    doi: 10.1093/toxres/tfaf064

    Effects of cytotoxicity observed with FTY720 (S)-P exposure on HepG2 cells after 24–48 and 72 h treatment. The cells were treated with 0.3125–10 μM concentrations.
    Figure Legend Snippet: Effects of cytotoxicity observed with FTY720 (S)-P exposure on HepG2 cells after 24–48 and 72 h treatment. The cells were treated with 0.3125–10 μM concentrations.

    Techniques Used:

    Effects of FTY720-S(P) (0.3125–10 μM) on cell viability by A) MTT, B) LDH and C) NRU assays in HepG2 cells after 72 h treatments. The cells were treated with 0.3125–10 μM concentrations. Data are expressed as mean ± SD, * P < 0.05 and * * P < 0.01 versus the control group.
    Figure Legend Snippet: Effects of FTY720-S(P) (0.3125–10 μM) on cell viability by A) MTT, B) LDH and C) NRU assays in HepG2 cells after 72 h treatments. The cells were treated with 0.3125–10 μM concentrations. Data are expressed as mean ± SD, * P < 0.05 and * * P < 0.01 versus the control group.

    Techniques Used: Control

    Changes in the ATP content observed with FTY720 (S)-P exposure on HepG2 cells after 72 h treatment. The cells were treated with 0.625–10 μM concentrations. Data are expressed as mean ± SD, * P < 0.05 versus the control group.
    Figure Legend Snippet: Changes in the ATP content observed with FTY720 (S)-P exposure on HepG2 cells after 72 h treatment. The cells were treated with 0.625–10 μM concentrations. Data are expressed as mean ± SD, * P < 0.05 versus the control group.

    Techniques Used: Control

    Changes in mitochondrial membrane potential (MMP) observed with FTY720 (S)-P exposure on HepG2 cells after 72 h treatment. A) Quadrants of JC-1 aggregates (PE channel) and monomers (FITC channel), B) MMP levels. The cells were treated with 0.625–10 μM concentrations. Data are expressed as mean ± SD, * P < 0.05 and * * P < 0.01 versus the control group.
    Figure Legend Snippet: Changes in mitochondrial membrane potential (MMP) observed with FTY720 (S)-P exposure on HepG2 cells after 72 h treatment. A) Quadrants of JC-1 aggregates (PE channel) and monomers (FITC channel), B) MMP levels. The cells were treated with 0.625–10 μM concentrations. Data are expressed as mean ± SD, * P < 0.05 and * * P < 0.01 versus the control group.

    Techniques Used: Membrane, Control

    Oxidative stress production observed with FTY720 (S)-P exposure on HepG2 cells after 72 h treatment. A) Cellular ROS production, B) mitochondrial ROS production. The cells were treated with 0,625–10 μM concentrations. Data are expressed as mean ± SD, * P < 0.05, * * P < 0.01 versus the control group.
    Figure Legend Snippet: Oxidative stress production observed with FTY720 (S)-P exposure on HepG2 cells after 72 h treatment. A) Cellular ROS production, B) mitochondrial ROS production. The cells were treated with 0,625–10 μM concentrations. Data are expressed as mean ± SD, * P < 0.05, * * P < 0.01 versus the control group.

    Techniques Used: Control

    Changes in antioxidant enzyme levels observed with FTY720 (S)-P exposure on HepG2 cells after 72 h treatment. A) Total superoxide dismutase (T-SOD), B) glutathione (GSH), (C) catalase (CAT). The cells were treated with 0.625–10 μM concentrations. Data are expressed as mean ± SD, * P < 0.05, * * P < 0.01 versus the control group.
    Figure Legend Snippet: Changes in antioxidant enzyme levels observed with FTY720 (S)-P exposure on HepG2 cells after 72 h treatment. A) Total superoxide dismutase (T-SOD), B) glutathione (GSH), (C) catalase (CAT). The cells were treated with 0.625–10 μM concentrations. Data are expressed as mean ± SD, * P < 0.05, * * P < 0.01 versus the control group.

    Techniques Used: Control

    Molecular docking of FTY720 (S)-P depicted as 2D and 3D simulations within the binding sites of human SIRT3 (A) and SIRT5 (B), utilizing the X-ray crystallographic structures with PDB codes 4JSR and 5XHS, respectively.
    Figure Legend Snippet: Molecular docking of FTY720 (S)-P depicted as 2D and 3D simulations within the binding sites of human SIRT3 (A) and SIRT5 (B), utilizing the X-ray crystallographic structures with PDB codes 4JSR and 5XHS, respectively.

    Techniques Used: Binding Assay

    The Interaction profiles and docking scores of FTY720 (S)-P within the binding pocket of the SIRT3 (PDB ID: 4JSR) and SIRT5 (PDB ID: 5XHS) proteins.
    Figure Legend Snippet: The Interaction profiles and docking scores of FTY720 (S)-P within the binding pocket of the SIRT3 (PDB ID: 4JSR) and SIRT5 (PDB ID: 5XHS) proteins.

    Techniques Used: Binding Assay



    Similar Products

    fty720 (s)-p  (Cayman Chemical)
    90
    Cayman Chemical fty720 (s)-p
    Effects of cytotoxicity observed with <t>FTY720</t> (S)-P exposure on HepG2 cells after 24–48 and 72 h treatment. The cells were treated with 0.3125–10 μM concentrations.
    Fty720 (S) P, supplied by Cayman Chemical, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/fty720-p/pmc12050031-46-0-5?v=Cayman+Chemical
    Average 90 stars, based on 1 article reviews
    fty720 (s)-p - by Bioz Stars, 2026-07
    90/100 stars
    		  Buy from Supplier
    fty720-p  (Brinkmann Instruments)
    90
    Brinkmann Instruments fty720-p
    Effects of cytotoxicity observed with <t>FTY720</t> (S)-P exposure on HepG2 cells after 24–48 and 72 h treatment. The cells were treated with 0.3125–10 μM concentrations.
    Fty720 P, supplied by Brinkmann Instruments, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/fty720-p/pm39303855-24-1-13?v=Brinkmann+Instruments
    Average 90 stars, based on 1 article reviews
    fty720-p - by Bioz Stars, 2026-07
    90/100 stars
    		  Buy from Supplier
    fty720-p  (Cayman Chemical)
    90
    Cayman Chemical fty720-p
    Effects of cytotoxicity observed with <t>FTY720</t> (S)-P exposure on HepG2 cells after 24–48 and 72 h treatment. The cells were treated with 0.3125–10 μM concentrations.
    Fty720 P, supplied by Cayman Chemical, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/fty720-p/pm39030171-349-14-15?v=Cayman+Chemical
    Average 90 stars, based on 1 article reviews
    fty720-p - by Bioz Stars, 2026-07
    90/100 stars
    		  Buy from Supplier
    fty720-p  (Novartis)
    90
    Novartis fty720-p
    Effects of cytotoxicity observed with <t>FTY720</t> (S)-P exposure on HepG2 cells after 24–48 and 72 h treatment. The cells were treated with 0.3125–10 μM concentrations.
    Fty720 P, supplied by Novartis, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/fty720-p/pmc11066976-24-0-2?v=Novartis
    Average 90 stars, based on 1 article reviews
    fty720-p - by Bioz Stars, 2026-07
    90/100 stars
    		  Buy from Supplier
    fty720 phosphate (fty720-p)  (Cayman Chemical)
    90
    Cayman Chemical fty720 phosphate (fty720-p)
    Effects of cytotoxicity observed with <t>FTY720</t> (S)-P exposure on HepG2 cells after 24–48 and 72 h treatment. The cells were treated with 0.3125–10 μM concentrations.
    Fty720 Phosphate (Fty720 P), supplied by Cayman Chemical, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/fty720-p/pm37958656-459-12-16?v=Cayman+Chemical
    Average 90 stars, based on 1 article reviews
    fty720 phosphate (fty720-p) - by Bioz Stars, 2026-07
    90/100 stars
    		  Buy from Supplier
    fingolimod phosphate fty720-p  (Novartis)
    90
    Novartis fingolimod phosphate fty720-p
    Effects of cytotoxicity observed with <t>FTY720</t> (S)-P exposure on HepG2 cells after 24–48 and 72 h treatment. The cells were treated with 0.3125–10 μM concentrations.
    Fingolimod Phosphate Fty720 P, supplied by Novartis, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/fty720-p/pm37736841-51-3-10?v=Novartis
    Average 90 stars, based on 1 article reviews
    fingolimod phosphate fty720-p - by Bioz Stars, 2026-07
    90/100 stars
    		  Buy from Supplier
    fingolimod phosphate (fty720-p, fp)  (Novartis)
    90
    Novartis fingolimod phosphate (fty720-p, fp)
    Chemical structures of a sphingosine 1-phosphate, b <t>fingolimod,</t> c fingolimod phosphate, d bis-imidazolium functional monomer, and e divinylbenzene cross-linker
    Fingolimod Phosphate (Fty720 P, Fp), supplied by Novartis, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/fty720-p/pmc10567913-47-3-10?v=Novartis
    Average 90 stars, based on 1 article reviews
    fingolimod phosphate (fty720-p, fp) - by Bioz Stars, 2026-07
    90/100 stars
    		  Buy from Supplier

    Image Search Results


    Effects of cytotoxicity observed with FTY720 (S)-P exposure on HepG2 cells after 24–48 and 72 h treatment. The cells were treated with 0.3125–10 μM concentrations.

    Journal: Toxicology Research

    Article Title: In vitro investigation of the toxicological mechanisms of Fingolimod (S)-phosphate in HEPG2 cells

    doi: 10.1093/toxres/tfaf064

    Figure Lengend Snippet: Effects of cytotoxicity observed with FTY720 (S)-P exposure on HepG2 cells after 24–48 and 72 h treatment. The cells were treated with 0.3125–10 μM concentrations.

    Article Snippet: FTY720 (S)-P was purchased from Cayman Chemical Company (USA) and dissolved in dimethyl sulfoxide (DMSO).

    Techniques:

    Effects of FTY720-S(P) (0.3125–10 μM) on cell viability by A) MTT, B) LDH and C) NRU assays in HepG2 cells after 72 h treatments. The cells were treated with 0.3125–10 μM concentrations. Data are expressed as mean ± SD, * P < 0.05 and * * P < 0.01 versus the control group.

    Journal: Toxicology Research

    Article Title: In vitro investigation of the toxicological mechanisms of Fingolimod (S)-phosphate in HEPG2 cells

    doi: 10.1093/toxres/tfaf064

    Figure Lengend Snippet: Effects of FTY720-S(P) (0.3125–10 μM) on cell viability by A) MTT, B) LDH and C) NRU assays in HepG2 cells after 72 h treatments. The cells were treated with 0.3125–10 μM concentrations. Data are expressed as mean ± SD, * P < 0.05 and * * P < 0.01 versus the control group.

    Article Snippet: FTY720 (S)-P was purchased from Cayman Chemical Company (USA) and dissolved in dimethyl sulfoxide (DMSO).

    Techniques: Control

    Changes in the ATP content observed with FTY720 (S)-P exposure on HepG2 cells after 72 h treatment. The cells were treated with 0.625–10 μM concentrations. Data are expressed as mean ± SD, * P < 0.05 versus the control group.

    Journal: Toxicology Research

    Article Title: In vitro investigation of the toxicological mechanisms of Fingolimod (S)-phosphate in HEPG2 cells

    doi: 10.1093/toxres/tfaf064

    Figure Lengend Snippet: Changes in the ATP content observed with FTY720 (S)-P exposure on HepG2 cells after 72 h treatment. The cells were treated with 0.625–10 μM concentrations. Data are expressed as mean ± SD, * P < 0.05 versus the control group.

    Article Snippet: FTY720 (S)-P was purchased from Cayman Chemical Company (USA) and dissolved in dimethyl sulfoxide (DMSO).

    Techniques: Control

    Changes in mitochondrial membrane potential (MMP) observed with FTY720 (S)-P exposure on HepG2 cells after 72 h treatment. A) Quadrants of JC-1 aggregates (PE channel) and monomers (FITC channel), B) MMP levels. The cells were treated with 0.625–10 μM concentrations. Data are expressed as mean ± SD, * P < 0.05 and * * P < 0.01 versus the control group.

    Journal: Toxicology Research

    Article Title: In vitro investigation of the toxicological mechanisms of Fingolimod (S)-phosphate in HEPG2 cells

    doi: 10.1093/toxres/tfaf064

    Figure Lengend Snippet: Changes in mitochondrial membrane potential (MMP) observed with FTY720 (S)-P exposure on HepG2 cells after 72 h treatment. A) Quadrants of JC-1 aggregates (PE channel) and monomers (FITC channel), B) MMP levels. The cells were treated with 0.625–10 μM concentrations. Data are expressed as mean ± SD, * P < 0.05 and * * P < 0.01 versus the control group.

    Article Snippet: FTY720 (S)-P was purchased from Cayman Chemical Company (USA) and dissolved in dimethyl sulfoxide (DMSO).

    Techniques: Membrane, Control

    Oxidative stress production observed with FTY720 (S)-P exposure on HepG2 cells after 72 h treatment. A) Cellular ROS production, B) mitochondrial ROS production. The cells were treated with 0,625–10 μM concentrations. Data are expressed as mean ± SD, * P < 0.05, * * P < 0.01 versus the control group.

    Journal: Toxicology Research

    Article Title: In vitro investigation of the toxicological mechanisms of Fingolimod (S)-phosphate in HEPG2 cells

    doi: 10.1093/toxres/tfaf064

    Figure Lengend Snippet: Oxidative stress production observed with FTY720 (S)-P exposure on HepG2 cells after 72 h treatment. A) Cellular ROS production, B) mitochondrial ROS production. The cells were treated with 0,625–10 μM concentrations. Data are expressed as mean ± SD, * P < 0.05, * * P < 0.01 versus the control group.

    Article Snippet: FTY720 (S)-P was purchased from Cayman Chemical Company (USA) and dissolved in dimethyl sulfoxide (DMSO).

    Techniques: Control

    Changes in antioxidant enzyme levels observed with FTY720 (S)-P exposure on HepG2 cells after 72 h treatment. A) Total superoxide dismutase (T-SOD), B) glutathione (GSH), (C) catalase (CAT). The cells were treated with 0.625–10 μM concentrations. Data are expressed as mean ± SD, * P < 0.05, * * P < 0.01 versus the control group.

    Journal: Toxicology Research

    Article Title: In vitro investigation of the toxicological mechanisms of Fingolimod (S)-phosphate in HEPG2 cells

    doi: 10.1093/toxres/tfaf064

    Figure Lengend Snippet: Changes in antioxidant enzyme levels observed with FTY720 (S)-P exposure on HepG2 cells after 72 h treatment. A) Total superoxide dismutase (T-SOD), B) glutathione (GSH), (C) catalase (CAT). The cells were treated with 0.625–10 μM concentrations. Data are expressed as mean ± SD, * P < 0.05, * * P < 0.01 versus the control group.

    Article Snippet: FTY720 (S)-P was purchased from Cayman Chemical Company (USA) and dissolved in dimethyl sulfoxide (DMSO).

    Techniques: Control

    Molecular docking of FTY720 (S)-P depicted as 2D and 3D simulations within the binding sites of human SIRT3 (A) and SIRT5 (B), utilizing the X-ray crystallographic structures with PDB codes 4JSR and 5XHS, respectively.

    Journal: Toxicology Research

    Article Title: In vitro investigation of the toxicological mechanisms of Fingolimod (S)-phosphate in HEPG2 cells

    doi: 10.1093/toxres/tfaf064

    Figure Lengend Snippet: Molecular docking of FTY720 (S)-P depicted as 2D and 3D simulations within the binding sites of human SIRT3 (A) and SIRT5 (B), utilizing the X-ray crystallographic structures with PDB codes 4JSR and 5XHS, respectively.

    Article Snippet: FTY720 (S)-P was purchased from Cayman Chemical Company (USA) and dissolved in dimethyl sulfoxide (DMSO).

    Techniques: Binding Assay

    The Interaction profiles and docking scores of FTY720 (S)-P within the binding pocket of the SIRT3 (PDB ID: 4JSR) and SIRT5 (PDB ID: 5XHS) proteins.

    Journal: Toxicology Research

    Article Title: In vitro investigation of the toxicological mechanisms of Fingolimod (S)-phosphate in HEPG2 cells

    doi: 10.1093/toxres/tfaf064

    Figure Lengend Snippet: The Interaction profiles and docking scores of FTY720 (S)-P within the binding pocket of the SIRT3 (PDB ID: 4JSR) and SIRT5 (PDB ID: 5XHS) proteins.

    Article Snippet: FTY720 (S)-P was purchased from Cayman Chemical Company (USA) and dissolved in dimethyl sulfoxide (DMSO).

    Techniques: Binding Assay

    Chemical structures of a sphingosine 1-phosphate, b fingolimod, c fingolimod phosphate, d bis-imidazolium functional monomer, and e divinylbenzene cross-linker

    Journal: Analytical and Bioanalytical Chemistry

    Article Title: Enhanced selective capture of phosphomonoester lipids enabling highly sensitive detection of sphingosine 1-phosphate

    doi: 10.1007/s00216-023-04937-8

    Figure Lengend Snippet: Chemical structures of a sphingosine 1-phosphate, b fingolimod, c fingolimod phosphate, d bis-imidazolium functional monomer, and e divinylbenzene cross-linker

    Article Snippet: Fingolimod (FTY720) and fingolimod phosphate (FTY720-P, FP) were purchased from Novartis Institutes for BioMedical Research (Basel, Switzerland).

    Techniques: Functional Assay